- Calpain 1 Antibody
- MyBioSource.com
- Pricing InfoSupplier PageView Company Product Page
- MBS4381357
- 0.02 mg (With BSA & Azide at 0.2mg/ml)
- Monoclonal
- Human
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
- ELISA (EIA), Immunohistochemistry (IHC) Paraffin
- Mouse
- 80kDa
- Calpain 1
- Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
- calpain 1
- CANP1, muCANP, CANP, muCL, CANPL1, SPG76
- Unconjugated
- IgG1 kappa
- CAPN1/1530
Specifications/Features
Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction